biologyRP1 · Cell BiologyPaper 1Combined and Separate

Microscopy

Method overview

Place a thin specimen on a slide, add an appropriate stain, lower a coverslip at an angle, begin with the lowest-power objective, focus, then increase magnification. Produce a clear biological drawing with labels and a scale or magnification.

Apparatus set-up

Diagram
Light microscope
Prepared slide + coverslip
Stain (e.g. iodine)

light microscope; slide; coverslip; specimen; stain; forceps; mounted needle

Independent variable

specimen or magnification used

Dependent variable

visible cell structures and measured image size

Control variables

same microscope calibration; same staining approach when comparing

Apparatus

light microscope; slide; coverslip; specimen; stain; forceps; mounted needle

Safety

Handle glass slides and stains carefully; use forceps or a mounted needle rather than fingers.

Scientific rationale

A thin specimen lets light pass through; stain increases contrast; lowering the coverslip at an angle reduces trapped air bubbles.

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